Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	115511
Country	Portugal

Category	Nutrition & Dietetics
Manuscript Type	Review
Article Title	Colorectal cancer therapy and nutrition: From ultra-processed consumption to metabolic reprogramming
Manuscript Source	Invited Manuscript
All Author List	Rodrigo Soares Pereira Lima, Jheniffer da Silva Sousa, Maria Shelda de Oliveira Neres, Dallyla Jennifer Morais de Sousa, Jorddam Almondes Martins, Irislene Costa Pereira, Alda Cássia Alves da Silva, Juliana Soares Severo, Francisco Leonardo Torres-Leal and Moisés Tolentino Bento da Silva
Funding Agency and Grant Number
Corresponding Author	Moisés Tolentino Bento da Silva, Assistant Professor, Laboratory of Physiology, Center for Drug Discovery and Innovative Medicines/RISE-Health: Health Research Network, Department of Immuno-Physiology and Pharmacology, School of Medicine and Biomedical Science, University of Porto, Jorge Viterbo Ferreira Street, 228, Porto 4050-313, Portugal. mtsilva@icbas.up.pt
Key Words	Colorectal cancer; Nutrition; Ultra-processed foods; Gut; Gastrointestinal tract
Core Tip	Dietary modulation may represent a relevant preventive and supportive strategy in colorectal cancer. Dietary patterns characterized by higher intake of fiber and bioactive compounds, such as those derived from whole grains, fruits, and vegetables, and lower consumption of ultra-processed foods have been associated with improved intestinal and metabolic homeostasis. In selected patients and under professional supervision, metabolically targeted interventions such as time-restricted eating, caloric restriction, or fasting-mimicking diets may be considered as adjunctive approaches, based on their mechanistic links to tumor metabolism, inflammation, and host metabolic reprogramming. These strategies should be individualized, carefully monitored, and applied as complements to standard oncologic care.
Citation	Lima RSP, Sousa JDS, Neres MSO, de Sousa DJM, Martins JA, Pereira IC, da Silva ACA, Severo JS, Torres-Leal FL, da Silva MTB. Colorectal cancer therapy and nutrition: From ultra-processed consumption to metabolic reprogramming. World J Gastrointest Oncol 2026; In press

Received	2025-10-20 00:35
Peer-Review Started	2025-10-20 00:35
First Decision by Editorial Office Director	2025-11-24 12:04
Return for Revision	2025-11-24 12:04
Revised	2025-12-09 10:07
Publication Fee Transferred
Second Decision by Editor	2026-01-16 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-16 06:42
Articles in Press	2026-01-16 06:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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