Publication Name	World Journal of Hepatology
Manuscript ID	115514
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Gut microbiota-bile acid crosstalk: Prevotellaceae NK3B31 and 7-ketolithocholic acid drive metabolic benefits of distal bowel resection preserving terminal ileum
Manuscript Source	Invited Manuscript
All Author List	Xu Cui, Long-Yao Xu, Bing-Qian Yin, Liu Chen, Zheng Liang and Chao-Ming Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Fujian Provincial Science and Technology Innovation Joint Fund Project No.2024Y9555 Fujian Provincial Natural Science Foundation Project No.2025J01226 Fuian Provincial Medical Project for Creating Dual High-Ouality Development (High Level and High Standard) No.ETK2025004 Fujian Medical University Qihang Fund No.2023QH1239
Corresponding Author	Chao-Ming Zhou, Department of Pediatric Surgery, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 966 Hengyu Road, Fuzhou 350001, Fujian Province, China. fjsetyyzcm@163.com
Key Words	Distal bowel resection with terminal ileum preservation; Gut microbiota; Bile acid metabolism; Prevotellaceae NK3B31 group; 7-ketolithocholic acid; Glucose homeostasis
Core Tip	Xu et al revealed that the Prevotellaceae NK3B31 group/7-ketolithocholic acid (7-KLCA)/farnesoid X receptor (FXR) axis drives hepatic gluconeogenesis suppression in distal bowel resection with terminal ileum preservation; a metabolic surgery model. Multiomics linked microbial enrichment to 7-KLCA elevation and FXR activation, downregulating gluconeogenic genes. This improves understanding of gut microbiota–bile acid crosstalk, highlighting species-specific bile acid roles. Translational potential lies in targeting this axis (probiotics/7-KLCA analogs) for metabolic disease.
Citation	Cui X, Xu LY, Yin BQ, Chen L, Liang Z, Zhou CM. Gut microbiota-bile acid crosstalk: Prevotellaceae NK3B31 and 7-ketolithocholic acid drive metabolic benefits of distal bowel resection preserving terminal ileum. World J Hepatol 2026; In press

Received	2025-10-20 01:52
Peer-Review Started	2025-10-20 01:52
First Decision by Editorial Office Director	2025-11-24 12:53
Return for Revision	2025-11-24 15:47
Revised	2025-12-02 12:08
Publication Fee Transferred
Second Decision by Editor	2026-01-06 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-07 01:00
Articles in Press	2026-01-07 01:00
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com