Publication Name	World Journal of Gastroenterology
Manuscript ID	115526
Country	United Arab Emirates

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Ethnic divergence in human leukocyte antigen-linked immunogenicity in inflammatory bowel disease: Lessons from Taiwan
Manuscript Source	Invited Manuscript
All Author List	Taly Issa and Iyad Issa
Funding Agency and Grant Number
Corresponding Author	Iyad Issa, MD, Department of Gastroenterology and Hepatology, Harley Street Medical Center, Marina Village, Villa No. A21, Abu Dhabi 41475, United Arab Emirates. iyadissa71@gmail.com
Key Words	Inflammatory bowel disease; Anti-drug antibodies; Human leukocyte antigen genotyping; Immunogenicity; Pharmacogenomics; Precision medicine; Ethnic-specific alleles; Infliximab; Adalimumab; Therapeutic drug monitoring
Core Tip	This editorial highlights a pivotal study identifying HLA-C*03:04:01 and HLA-B*15:18:01 as ethnic-specific risk alleles for anti-drug antibody formation in Taiwanese inflammatory bowel disease patients treated with infliximab and adalimumab. These findings challenge the presumed universality of HLA-DQA1*05 and underscore the importance of integrating high-resolution human leukocyte antigen genotyping and therapeutic drug monitoring into personalized biologic therapy for diverse populations.
Citation	Issa T, Issa I. Ethnic divergence in human leukocyte antigen-linked immunogenicity in inflammatory bowel disease: Lessons from Taiwan. World J Gastroenterol 2026; In press

Received	2025-10-20 01:50
Peer-Review Started	2025-10-20 01:50
First Decision by Editorial Office Director	2025-12-24 10:20
Return for Revision	2025-12-24 10:20
Revised	2026-01-02 14:44
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 08:26
Articles in Press	2026-02-05 08:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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