Publication Name	World Journal of Gastroenterology
Manuscript ID	115533
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Vitamin D, vitamin D receptor gene polymorphisms, and inflammatory bowel disease outcomes: From molecular mechanisms to clinical application
Manuscript Source	Invited Manuscript
All Author List	Beatriz Gabriela Costa, Ryan Nunes Yoshio Yoshihara, Amanda Luísa Spiller, Natalia Salvador Castelhano, Andrey Santos, Júlio Pinheiro Baima, Marcello Imbrizi, Maiara Brusco De Freitas, Daniéla Oliveira Magro and Ligia Yukie Sassaki
Funding Agency and Grant Number
Corresponding Author	Ligia Yukie Sassaki, Assistant Professor, MD, PhD, Researcher, Department of Internal Medicine, Medical School, São Paulo State University (UNESP), Avenida Professor Montenegro, Distrito de Rubiao Junior, Botucatu 18618-686, São Paulo, Brazil. ligia.sassaki@unesp.br
Key Words	Vitamin D; Vitamin D receptor; Genetic polymorphisms; Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease
Core Tip	Vitamin D is essential in the pathogenesis and managing inflammatory bowel diseases. In addition to its classical bone metabolism function, vitamin D modulates intestinal epithelial integrity and immune responses. Genetic polymorphisms in the vitamin D receptor may influence disease activity and treatment outcomes. This minireview emphasizes the need for routine assessment of vitamin D status and consideration of vitamin D receptor genetic variants in personalized therapeutic strategies for inflammatory bowel diseases, especially in patients receiving immunosuppressive or biologic therapies.
Citation	Costa BG, Yoshihara RNY, Spiller AL, Castelhano NS, Santos A, Baima JP, Imbrizi M, De Freitas MB, Magro DO, Sassaki LY. Vitamin D, vitamin D receptor gene polymorphisms, and inflammatory bowel disease outcomes: From molecular mechanisms to clinical application. World J Gastroenterol 2026; In press

Received	2025-10-20 01:49
Peer-Review Started	2025-10-20 01:49
First Decision by Editorial Office Director	2025-10-23 09:28
Return for Revision	2025-10-23 09:28
Revised	2025-10-30 00:41
Publication Fee Transferred
Second Decision by Editor	2026-02-02 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-02 22:59
Articles in Press	2026-02-02 22:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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