Publication Name	World Journal of Gastroenterology
Manuscript ID	115536
Country	Thailand

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Reprogramming of amino acid metabolism in cholangiocarcinoma: A potential target for metabolic-targeted therapy
Manuscript Source	Invited Manuscript
All Author List	Kullanat Khawkhiaw, Worachart Lert-Itthiporn, Naisana Seyedasli, Ching-Feng Chiu and Charupong Saengboonmee
Funding Agency and Grant Number	Funding Agency Grant Number Mekong - Lancang Cooperation Special Fund Development and Promotion of Science and Technology Talents Project, Institute for the Promotion of Teaching Science and Technology of Thailand
Corresponding Author	Charupong Saengboonmee, Associate Professor, MD, PhD, Department of Biochemistry, Faculty of Medicine, Khon Kaen University, 123 Mittraphap Highway, Khon Kaen 40002, Thailand. charusa@kku.ac.th
Key Words	Amino acid; Biliary tract cancer; Cancer metabolism; Cholangiocarcinoma; Metabolic reprogramming
Core Tip	Metabolic reprogramming is a malignant hallmark found in many types of cancer, including cholangiocarcinoma (CCA). A higher requirement and dependency of certain amino acids is found in CCA and is generally associated with aggressive phenotypes of cancer cells, leading to poor prognosis of patients. In this article, amino acids with reports of their significance in CCA development and progression are reviewed. The mechanisms underlying amino acid metabolic reprogramming and their networks with intracellular signaling are also discussed. Up-to-date interventions and the opportunity for metabolic targeting in CCA treatment are proposed.
Citation	Khawkhiaw K, Lert-Itthiporn W, Seyedasli N, Chiu CF, Saengboonmee C. Reprogramming of amino acid metabolism in cholangiocarcinoma: A potential target for metabolic-targeted therapy. World J Gastroenterol 2026; In press

Received	2025-10-20 01:46
Peer-Review Started	2025-10-20 01:46
First Decision by Editorial Office Director	2025-12-12 09:12
Return for Revision	2025-12-12 09:12
Revised	2025-12-25 20:47
Publication Fee Transferred
Second Decision by Editor	2026-02-09 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 11:44
Articles in Press	2026-02-09 11:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com