Publication Name	World Journal of Orthopedics
Manuscript ID	115537
Country	Saudi Arabia

Category	Orthopedics
Manuscript Type	Retrospective Cohort Study
Article Title	Significant quality of life improvement following total knee replacement for end-stage osteoarthritis: Retrospective cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Mohammed H Abushal, Osama M Embaby, Mahmoud Mersal, Emran Badghish and Mohamed Elalfy
Funding Agency and Grant Number
Corresponding Author	Mohammed H Abushal, Assistant Professor, Department of Orthopedic Surgery, University of Tabuk, Duba Road, University City, Tabuk 71491, Saudi Arabia. mabushal@ut.edu.sa
Key Words	Total knee replacement; Knee osteoarthritis; Health-related quality of life; Patient-reported outcome measures; Conservative management; Retrospective cohort study
Core Tip	Total knee replacement is a highly effective procedure for improving the quality of life in patients with severe knee osteoarthritis. This retrospective cohort study from a major Saudi Arabian orthopedic center provides strong evidence that surgical intervention offers substantial and clinically meaningful benefits over conservative management, as measured by the EuroQol five-dimension, five-level questionnaire patient-reported outcome measure. These findings support prioritizing timely surgical referrals for eligible candidates to maximize improvements in health-related quality of life.
Citation	Abushal MH, Embaby OM, Mersal M, Badghish E, Elalfy M. Significant quality of life improvement following total knee replacement for end-stage osteoarthritis: Retrospective cohort study. World J Orthop 2025; In press

Received	2025-10-20 10:21
Peer-Review Started	2025-10-20 10:21
First Decision by Editorial Office Director	2025-11-04 09:31
Return for Revision	2025-11-04 09:31
Revised	2025-11-04 17:59
Publication Fee Transferred	2025-11-06 15:07
Second Decision by Editor	2025-12-17 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-17 09:51
Articles in Press	2025-12-17 09:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com