Publication Name	World Journal of Hepatology
Manuscript ID	115539
Country	Peru

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Dyslipidemia in liver cirrhosis: Pathophysiology and emerging therapeutic approaches
Manuscript Source	Invited Manuscript
All Author List	Jenyfer M Fuentes-Mendoza, Marcio J Concepción-Zavaleta, Jeny J Mendoza-Godoy, Luis A Concepción-Urteaga, Carlos O Martínez-Gutiérrez and José Paz-Ibarra
Funding Agency and Grant Number
Corresponding Author	Marcio J Concepción-Zavaleta, Grupo de Investigación en Neurociencias, Metabolismo, Efectividad Clínica y Salud Pública, Universidad Científica del Sur, 19 Panamericana Sur, Villa El Salvador, Lima 15067, Peru. mconcepcion@cientifica.edu.pe
Key Words	Liver cirrhosis; Dyslipidemia; Hepatic lipid metabolism; Lipoprotein dysfunction; Cholestasis; Cardiometabolic risk
Core Tip	Dyslipidemia in liver cirrhosis reflects fundamental alterations in hepatic lipid biology, including impaired apolipoprotein synthesis, defective lipoprotein export, receptor downregulation, and cholestasis-driven accumulation of atypical particles such as lipoprotein X and lipoprotein Z. These molecular disturbances generate stage-specific lipid phenotypes that challenge conventional cardiovascular risk assessment and drug targeting. Non-statin lipid-lowering agents provide mechanistically informative tools to probe these disrupted pathways; however, their effects in cirrhosis remain largely defined by pharmacologic rationale rather than direct clinical evidence. Understanding how disease stage and etiology reshape hepatic lipid handling is essential for rational application and future development of lipid-modifying strategies in cirrhotic populations.
Citation	Fuentes-Mendoza JM, Concepción-Zavaleta MJ, Mendoza-Godoy JJ, Concepción-Urteaga LA, Martínez-Gutiérrez CO, Paz-Ibarra J. Dyslipidemia in liver cirrhosis: Pathophysiology and emerging therapeutic approaches. World J Hepatol 2026; In press

Received	2025-10-20 01:27
Peer-Review Started	2025-10-20 01:27
First Decision by Editorial Office Director	2025-10-30 09:17
Return for Revision	2025-10-30 09:17
Revised	2025-11-12 01:00
Publication Fee Transferred
Second Decision by Editor	2026-01-21 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-21 07:55
Articles in Press	2026-01-21 07:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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