Publication Name	World Journal of Gastroenterology
Manuscript ID	115543
Country	China

Category	Medicine, General & Internal
Manuscript Type	Letter to the Editor
Article Title	Herbal medicine beyond probiotics: Yiyi Fuzi Baijiang powder and the holistic regulation of gut microbiota in ulcerative colitis
Manuscript Source	Invited Manuscript
All Author List	Hua-Jun Zhang, Shui-Quan Jin, Ding-Jun Cai and Zhi-Peng He
Funding Agency and Grant Number
Corresponding Author	Zhi-Peng He, MD, Professor, Department of Breast Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), No. 54 Youdian Road, Shangcheng District, Hangzhou 310000, Zhejiang Province, China. hezhipeng0901@163.com
Key Words	Yiyi Fuzi Baijiang powder; Ulcerative colitis; Gut microbiota; Network pharmacology; Short-chain fatty acids; Multi-omics integration; Nuclear factor kappa-B signaling pathway; Synergistic mechanism
Core Tip	Yiyi Fuzi Baijiang powder (YFB) represents a paradigm shift in treating ulcerative colitis. Unlike conventional probiotics, YFB restores gut ecosystem equilibrium via a dual pathway: Its compounds directly mitigate inflammation while normalizing the intestinal oxygen landscape. This rectifies the hypoxic environment, explaining the paradoxical reduction of overgrown anaerobes like Bifidobacterium as a sign of ecosystem recovery, not a drawback. Integrating multi-omics techniques reveals YFB’s holistic, synergistic mechanism. Future work should employ molecular dynamics and metabolite assays to further decipher this sophisticated system-rebalancing approach.
Citation	Zhang HJ, Jin SQ, Cai DJ, He ZP. Herbal medicine beyond probiotics: Yiyi Fuzi Baijiang powder and the holistic regulation of gut microbiota in ulcerative colitis. World J Gastroenterol 2025; In press

Received	2025-10-20 01:26
Peer-Review Started	2025-10-20 01:26
To Make the First Decision
Return for Revision	2025-10-29 09:34
Revised	2025-11-08 03:50
Second Decision	2025-11-18 01:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-18 09:38
Articles in Press	2025-11-18 09:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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