Publication Name	World Journal of Gastroenterology
Manuscript ID	115544
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Diagnosis and management of metabolic dysfunction-associated steatohepatitis in patients with chronic hepatitis B infection
Manuscript Source	Invited Manuscript
All Author List	Talal K Bhatti and Joseph K Lim
Funding Agency and Grant Number
Corresponding Author	Joseph K Lim, MD, Professor, Section of Digestive Diseases and Yale Liver Center, Yale University School of Medicine, 333 Cedar Street, LMP 1080, New Haven, CT 06520, United States. joseph.lim@yale.edu
Key Words	Hepatitis B virus; Hepatic steatosis; Metabolic syndrome; Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis; Liver fibrosis; Clinical outcomes
Core Tip	In context of a growing global burden of obesity and diabetes mellitus, metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic syndrome are increasingly observed in patients with chronic hepatitis B (CHB) virus infection. The relationship between hepatic steatosis and/or metabolic syndrome with CHB is complex and remains incompletely defined, although multiple cohort studies reveal an association with liver inflammation, liver fibrosis, hepatitis B virus (HBV)-related liver events such as cirrhosis, liver failure, and liver cancer, as well as biochemical and virologic response to antiviral therapy. Therefore, a dual diagnosis of MASLD and CHB, also termed met-HBV, may have important implications for management. Probable met-HBV can initially be identified on the basis of liver imaging, but a confirmed diagnosis can be established on vibration-controlled transient elastography-based controlled attenuation parameter score or liver biopsy. Patients diagnosed with met-HBV should undergo active management of MASLD and other manifestations of the metabolic syndrome. Future cohort studies and controlled trials are needed to inform evidence-based approaches to management.
Citation	Bhatti TK, Lim JK. Diagnosis and management of metabolic dysfunction-associated steatohepatitis in patients with chronic hepatitis B infection. World J Gastroenterol 2026; In press

Received	2025-10-20 02:05
Peer-Review Started	2025-10-20 02:05
First Decision by Editorial Office Director	2025-11-21 09:59
Return for Revision	2025-11-21 09:59
Revised	2025-12-02 22:02
Publication Fee Transferred
Second Decision by Editor	2026-01-14 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-14 08:40
Articles in Press	2026-01-14 08:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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