Publication Name	World Journal of Hepatology
Manuscript ID	115551
Country	India

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Ultrasound imaging in orthotopic hepatocellular carcinoma models: Promise, practicality, and points for refinement
Manuscript Source	Invited Manuscript
All Author List	Devlina Ghosh and Alok Kumar
Funding Agency and Grant Number
Corresponding Author	Devlina Ghosh, Assistant Professor, PhD, Department of Biochemistry, Saraswati Dental College and Hospital, 233 Tiwariganj, Ayodhya Road, Lucknow 226028, Uttar Pradesh, India. ghoshdevlin6@gmail.com
Key Words	Hepatocellular carcinoma; Ultrasound imaging; Histology; Tumor growth monitoring; Tumor volumetry
Core Tip	High frequency ultrasound is a rapid, low-cost, minimally invasive tool for serial volumetric monitoring of orthotopic hepatocellular carcinoma that correlates well with terminal histology and can match micro computed tomography (CT)/magnetic resonance imaging (MRI) for gross tumor size, but it lacks cellular resolution and remains operator-dependent. To increase translational impact, future work should standardize acquisition and training, perform multimodal validation in subset cohorts (histology, micro CT/MRI), and adopt contrast-enhanced/photoacoustic imaging, along with automated radiomics/artificial intelligence segmentation to reduce bias and improve sensitivity.
Citation	Ghosh D, Kumar A. Ultrasound imaging in orthotopic hepatocellular carcinoma models: Promise, practicality, and points for refinement. World J Hepatol 2025; In press

Received	2025-10-20 02:03
Peer-Review Started	2025-10-20 02:03
To Make the First Decision
Return for Revision	2025-10-23 08:23
Revised	2025-10-27 14:12
Second Decision	2025-11-24 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-24 06:32
Articles in Press	2025-11-24 06:32
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Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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