Publication Name	World Journal of Gastroenterology
Manuscript ID	115556
Country	China

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Efficacy and safety of sequential hyperthermic intraperitoneal chemotherapy following surgery for pathological T staging 4 gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Long Lian, Li-Sheng Cai, Ming-Qiao Lian, Ming-Jie Lian, Yu-Qin Sun, Chen-Bin Lv, Guo-Ping Huang, Rong-Jie Huang, Yong-Bin Zhang, Wei-Ming Zeng, Qian-Hui Xu, Quan-Jian Zhu and Qiu-Xian Chen
Funding Agency and Grant Number
Corresponding Author	Qiu-Xian Chen, Associate Chief Physician, Department of General Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, No. 9 Zhangma Road, Yancuo Town, Longhai District, Zhangzhou 363000, Fujian Province, China. chenqiuxian2024@163.com
Key Words	Hyperthermic intraperitoneal chemotherapy; Gastric cancer; Prognosis; Overall survival; Disease-free survival; Disease-free interval; Peritoneal metastasis-free interval
Core Tip	The efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) as a postoperative adjuvant therapy for locally advanced gastric cancer remains unclear. This study analyzed 225 patients with nonmetastatic pathological T staging 4 gastric adenocarcinoma and found that HIPEC plus adjuvant chemotherapy significantly improved disease-free survival and reduced the risk of peritoneal metastasis without additional adverse reactions in non-metastatic pathological T staging 4 gastric adenocarcinoma. These results establish HIPEC as a safe and effective adjuvant therapy for preventing postoperative recurrence and peritoneal dissemination.
Citation	Lian WL, Cai LS, Lian MQ, Lian MJ, Sun YQ, Lv CB, Huang GP, Huang RJ, Zhang YB, Zeng WM, Xu QH, Zhu QJ, Chen QX. Efficacy and safety of sequential hyperthermic intraperitoneal chemotherapy following surgery for pathological T staging 4 gastric cancer. World J Gastroenterol 2025; In press

Received	2025-10-21 06:58
Peer-Review Started	2025-10-21 06:59
First Decision by Editorial Office Director	2025-11-05 09:28
Return for Revision	2025-11-05 09:28
Revised	2025-11-17 14:47
Publication Fee Transferred	2025-11-20 15:18
Second Decision by Editor	2025-12-22 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-22 06:18
Articles in Press	2025-12-22 06:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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