Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	115576
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Hepatocellular carcinoma in F0 livers: Clinical and prognostic insights
Manuscript Source	Unsolicited Manuscript
All Author List	Mizuki Endo, Koichi Honda, Tomoko Tokumaru, Tomoko Saito, Takuro Uchida, Masao Iwao, Mie Arakawa, Masataka Seike, Masaaki Kodama, Takashi Masuda, Yuichi Endo, Masafumi Inomata, Kazunari Murakami and Kazuhiro Mizukami
Funding Agency and Grant Number
Corresponding Author	Mizuki Endo, Assistant Professor, Department of Gastroenterology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-Machi, Yufu 879-5593, Oita, Japan. emizuki@oita-u.ac.jp
Key Words	Hepatocellular carcinoma; Nonfibrotic liver; Prognosis; Recurrence; Collaboration
Core Tip	Hepatocellular carcinoma (HCC) arising in nonfibrotic (F0) livers is uncommon and its clinical behavior remains unclear. This study directly compared F0 and cirrhotic (F4) HCC, revealing that F0 HCC typically occurs in older men with negative for both hepatitis B and C etiology and larger tumors. Despite preserved liver function, recurrence significantly worsened prognosis. Tumor number was the sole independent risk factor for recurrence in F0 HCC. These findings emphasize the need for early detection strategies, even in non-cirrhotic populations.
Citation	Endo M, Honda K, Tokumaru T, Saito T, Uchida T, Iwao M, Arakawa M, Seike M, Kodama M, Masuda T, Endo Y, Inomata M, Murakami K, Mizukami K. Hepatocellular carcinoma in F0 livers: Clinical and prognostic insights. World J Gastrointest Oncol 2026; In press

Received	2025-10-21 07:00
Peer-Review Started	2025-10-21 07:00
First Decision by Editorial Office Director	2025-12-16 09:49
Return for Revision	2025-12-16 12:33
Revised	2025-12-29 08:49
Publication Fee Transferred	2026-01-05 00:40
Second Decision by Editor	2026-02-04 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 07:20
Articles in Press	2026-02-04 07:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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