Publication Name	World Journal of Hepatology
Manuscript ID	115582
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Cell-free DNA in hepatocellular carcinoma: Biology to treatment response
Manuscript Source	Invited Manuscript
All Author List	Rishabh Sharma, Satender Pal Singh, Garima Bhatia and Gayatri Ramakrishna
Funding Agency and Grant Number
Corresponding Author	Satender Pal Singh, Department of Hepatology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, Delhi 110070, India. ama.satender@gmail.com
Key Words	Cell-free DNA; Circulating tumor DNA; Hepatocellular carcinoma; Liquid biopsy; Methylation; Fragmentomics; Copy number variation; Chromosomal instability; Minimal residual disease; Treatment response
Core Tip	The study evaluated circulating tumor DNA as a potential indicator of treatment response in hepatocellular carcinoma. Quantitative aspects of cell-free DNA, such as concentration and variant allele frequency, were analyzed in conjunction with qualitative genomic and epigenetic features, including copy-number variation and methylation-associated changes, to assess tumor dynamics during therapy. The findings indicate that cell-free DNA profiling captures both quantitative changes and molecular alterations, including genomic and epigenetic variation, that may reflect treatment-related tumor dynamics in hepatocellular carcinoma.
Citation	Sharma R, Singh SP, Bhatia G, Ramakrishna G. Cell-free DNA in hepatocellular carcinoma: Biology to treatment response. World J Hepatol 2026; In press

Received	2025-10-22 11:10
Peer-Review Started	2025-10-22 11:10
First Decision by Editorial Office Director	2025-10-29 08:34
Return for Revision	2025-10-29 08:34
Revised	2025-11-11 11:48
Publication Fee Transferred
Second Decision by Editor	2026-01-20 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-20 09:16
Articles in Press	2026-01-20 09:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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