Publication Name	World Journal of Diabetes
Manuscript ID	115619
Country	China

Category	Public, Environmental & Occupational Health
Manuscript Type	Minireviews
Article Title	Dual effects of synthetic phenolic antioxidants in type 2 diabetes mellitus: Mechanisms and advances
Manuscript Source	Invited Manuscript
All Author List	Xin Li, Peng-Cheng Yuan, Qian Gao, Qing-Qing Cao, Zhen Ma, Xuan Chen, Chong-Jian Wang, Zhen-Xing Mao and Wen-Qian Huo
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 21806146 Postdoctoral Science Foundation of China No. 2021M702934
Corresponding Author	Wen-Qian Huo, Associate Professor, PhD, Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou 450001, Henan Province, China. huowenqian@zzu.edu.cn
Key Words	Synthetic phenolic antioxidants; Type 2 diabetes mellitus; Dual effects; Butylated hydroxyanisole; Butylated hydroxytoluene; Tert-butylhydroquinone
Core Tip	This review is the first to systematically elucidate the dual regulatory role of synthetic phenolic antioxidants in the development of type 2 diabetes mellitus, identifying the balance of the nuclear factor erythroid 2-related factor 2/nuclear factor kappa-light-chain-enhancer of activated B cells pathway as the core regulatory mechanism. However, it must be acknowledged that current evidence predominantly comes from preclinical studies, making it difficult to extrapolate the findings to human populations.
Citation	Li X, Yuan PC, Gao Q, Cao QQ, Ma Z, Chen X, Wang CJ, Mao ZX, Huo WQ. Dual effects of synthetic phenolic antioxidants in type 2 diabetes mellitus: Mechanisms and advances. World J Diabetes 2026; In press

Received	2025-10-24 00:47
Peer-Review Started	2025-10-24 09:12
First Decision by Editorial Office Director	2025-11-25 07:49
Return for Revision	2025-11-25 07:49
Revised	2025-12-17 08:35
Publication Fee Transferred
Second Decision by Editor	2026-02-06 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 04:00
Articles in Press	2026-02-06 04:00
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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