Publication Name	World Journal of Critical Care Medicine
Manuscript ID	115620
Country	Greece

Category	Critical Care Medicine
Manuscript Type	Case Report
Article Title	Myoclonus associated with tranexamic acid administration in a patient on veno-arterial extracorporeal membrane oxygenation support: A case report
Manuscript Source	Invited Manuscript
All Author List	Fotios Dimitriadis, Theodoros Pitsolis, Kyriaki Kolovou, Theodosia Maragkoulia, Evangelia Theodorou, Giorgos Konstantinou, Theodora Soulele, Ioannis Vlahodimitris, Michail Zervos, Paraskevi Salata, Dimitrios Elaiopoulos, Stergios Gatzonis and Stavros Dimopoulos
Funding Agency and Grant Number
Corresponding Author	Stavros Dimopoulos, PhD, Cardiac Surgery Intensive Care Unit, Onassis Cardiac Surgery Center, 356 Syggrou Av, Athens 17674, Attikí, Greece. stdimop@gmail.com
Key Words	Tranexamic acid; Extracorporeal membrane oxygenation; Myoclonic jerks; Continuous renal replacement therapy; Overdose; Case report
Core Tip	This article describes the first known case of tranexamic acid (TXA)-induced myoclonus in a patient receiving veno-arterial extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy. TXA accumulation due to impaired renal clearance led to neurotoxicity, which resolved after drug discontinuation. The case underscores the need for individualized TXA dosing and vigilant neurological monitoring in ECMO patients with renal dysfunction, given the absence of standardized dosing protocols and the delicate hemostatic balance in this setting.
Citation	Dimitriadis F, Pitsolis T, Kolovou K, Maragoulia S, Theodorou E, Konstantinou G, Soulele T, Vlahodimitris I, Zervos M, Salata P, Elaiopoulos D, Gatzonis S, Dimopoulos S. Myoclonus associated with tranexamic acid administration in a patient on veno-arterial extracorporeal membrane oxygenation support: A case report. World J Crit Care Med 2026; In press

Received	2025-10-21 05:34
Peer-Review Started	2025-10-21 05:36
First Decision by Editorial Office Director	2025-11-04 09:36
Return for Revision	2025-11-04 09:36
Revised	2025-12-10 14:17
Publication Fee Transferred
Second Decision by Editor	2026-01-21 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-21 06:27
Articles in Press	2026-01-21 06:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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