Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115621
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Correlation between the initiation of early enteral nutrition and anastomotic fistula after pancreaticoduodenectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Bei Yan, Li-Qun Zhang and Yi-Qing Shen
Funding Agency and Grant Number
Corresponding Author	Yi-Qing Shen, Chief Nurse, Department of Comprehensive Surgery the Transformation Center, First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. 1149750425@qq.com
Key Words	Pancreaticoduodenectomy; Early enteral nutrition; Postoperative anastomotic leakage; Nutritional status; Time to recovery
Core Tip	This retrospective cohort study, involving data from 200 patients who underwent pancreaticoduodenectomy, revealed that initiating early enteral nutrition (EEN) ≤ 24 hours versus > 72 hours postoperatively, was an independent protective factor against total anastomotic leakage and clinically relevant (grade B/C) pancreatic fistulas. EEN was also associated with significantly improved nutritional status (serum albumin, prealbumin, and transferrin levels), accelerated recovery of gastrointestinal function, and shortened hospital stay. These findings challenge traditional delayed feeding practices and support the integration of EEN into enhanced recovery pathways for this major surgery.
Citation	Yan B, Zhang LQ, Shen YQ. Correlation between the initiation of early enteral nutrition and anastomotic fistula after pancreaticoduodenectomy. World J Gastrointest Surg 2026; In press

Received	2025-11-21 09:23
Peer-Review Started	2025-11-21 09:23
First Decision by Editorial Office Director	2025-12-12 07:44
Return for Revision	2025-12-12 07:44
Revised	2025-12-25 15:47
Publication Fee Transferred	2025-12-29 07:25
Second Decision by Editor	2026-01-22 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-22 03:15
Articles in Press	2026-01-22 03:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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