Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115622
Country	Kenya

Category	Surgery
Manuscript Type	Letter to the Editor
Article Title	Prognostic value of primary tumor site in surgery for colorectal liver metastases
Manuscript Source	Invited Manuscript
All Author List	Felix P Omullo
Funding Agency and Grant Number
Corresponding Author	Felix P Omullo, MD, Senior Researcher, Department of Medical Services, Equity Afya, Kanaamkemer, Lodwar 399-30500, Turkana, Kenya. piuskirasia@gmail.com
Key Words	Colorectal liver metastases; Tumor location; Right-sided colon cancer; Surgical outcomes; Prognostic stratification; Cancer recurrence
Core Tip	Primary tumor location is a master prognostic regulator in colorectal liver metastases. Right-sided origin defines an aggressive biologic phenotype, marked by chemoresistance, hypercoagulability, and systemic decline, culminating in a more than 50% 1-year recurrence rate and a 13-month survival deficit. These findings mandate abandoning a one-size-fits-all management approach. Therefore, the immediate implementation of the following site-specific protocols remains paramount: Preoperative risk stratification, therapeutic intensification, and personalized intensive surveillance for right-sided cases.
Citation	Omullo FP. Prognostic value of primary tumor site in surgery for colorectal liver metastases. World J Gastrointest Surg 2025; In press

Received	2025-10-21 04:58
Peer-Review Started	2025-10-21 05:00
First Decision by Editorial Office Director	2025-10-24 10:50
Return for Revision	2025-10-24 10:50
Revised	2025-10-24 13:47
Publication Fee Transferred
Second Decision by Editor	2025-12-17 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-17 10:28
Articles in Press	2025-12-17 10:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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