Publication Name	World Journal of Stem Cells
Manuscript ID	115658
Country	Pakistan

Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Wound pathophysiology and healing dynamics for stem cell-mediated therapeutics in different skin wounds
Manuscript Source	Invited Manuscript
All Author List	Fatima Jameel, Iqra Sahibdad, Sidra Ghulam Muhammad and Asmat Salim
Funding Agency and Grant Number
Corresponding Author	Asmat Salim, Stem Cell Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, ICCBS, University of Karachi, Main University Road, Karachi 75270, Sindh, Pakistan. asmat.salim@iccs.edu
Key Words	Wound healing; Mesenchymal stem cells; Regenerative medicine; Preconditioning; Biomaterials; Clinical translation
Core Tip	Skin wound healing is a complex process affected by the type and severity of injury. This review provides a comparative overview of the pathophysiology of excisional, thermal, chemical, and cold-induced skin wounds while highlighting mesenchymal stem cell (MSC)-based regenerative strategies. It explains how MSCs modulate inflammation, promote angiogenesis, and support tissue remodeling through paracrine and immunomodulatory mechanisms. Additionally, it emphasizes optimizing MSC therapy via preconditioning (chemical, hypoxic, or genetic) and combining it with biomaterials like hydrogels and scaffolds to improve survival, engraftment, and functional recovery. The review also addresses translational barriers and the need for standardization in clinical applications, underscoring the potential of MSC-based treatments as future-oriented options for complex skin injuries.
Citation	Jameel F, Sahibdad I, Muhammad SG, Salim A. Wound pathophysiology and healing dynamics for stem cell-mediated therapeutics in different skin wounds. World J Stem Cells 2026; In press

Received	2025-10-22 06:07
Peer-Review Started	2025-10-22 06:07
First Decision by Editorial Office Director	2025-11-21 07:05
Return for Revision	2025-11-21 07:05
Revised	2025-12-04 19:36
Publication Fee Transferred
Second Decision by Editor	2026-01-26 05:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 01:49
Articles in Press	2026-02-03 01:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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