Publication Name	World Journal of Hepatology
Manuscript ID	115659
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Kaempferol attenuates diet-induced obesity and hepatic steatosis in C57BL/6J mice fed an Indian diet-mimicking regimen
Manuscript Source	Invited Manuscript
All Author List	Bhagyalakshmi Nair, Rajesh Gopalakrishna and Lekshmi R Nath
Funding Agency and Grant Number	Funding Agency Grant Number the Amrita Vishwa Vidyapeetham Seed Grant K-PHAR-22-662
Corresponding Author	Lekshmi R Nath, Associate Professor, PhD, Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Ponekkara PO, Kochi 682041, Kerala, India. lekshmirnath@aims.amrita.edu
Key Words	Metabolic dysfunction-associated steatotic liver disease; Indian high fat diet; High calorie diet; Natural product; Kaempferol; Hepatic steatosis
Core Tip	Metabolic dysfunction-associated steatotic liver disease spans from simple fat accumulation to cirrhosis and liver cancer, and its prevalence is steadily rising in India due to high fat, high sugar dietary habits. Kaempferol, a generally recognized as safe-approved flavonoid lipid-lowering effects, shows therapeutic potential but has not yet been evaluated in Indian diet-specific obesity driven liver disease models. This study demonstrates that kaempferol effectively attenuates diet-induced obesity and liver steatosis in C57BL/6J mice fed an Indian diet-mimicking regimen. The findings highlight kaempferol’s potential as a natural therapeutic agent for managing metabolic dysfunction and fatty liver disease associated with high calorie, region-specific dietary patterns.
Citation	Nair B, Gopalakrishna R, Nath LR. Kaempferol attenuates diet-induced obesity and hepatic steatosis in C57BL/6J mice fed an Indian diet-mimicking regimen. World Journal of Hepatol 2026; In press

Received	2025-10-24 05:15
Peer-Review Started	2025-10-24 05:15
First Decision by Editorial Office Director	2025-11-18 10:59
Return for Revision	2025-11-18 11:08
Revised	2025-12-01 07:41
Publication Fee Transferred
Second Decision by Editor	2026-02-04 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 06:20
Articles in Press	2026-02-04 06:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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