Publication Name	World Journal of Orthopedics
Manuscript ID	115663
Country	Italy

Category	Orthopedics
Manuscript Type	Review
Article Title	Kidney-bone axis: Emerging paradigms in cross-talk between renal function and skeletal health
Manuscript Source	Invited Manuscript
All Author List	Guido Gembillo, Concetto Sessa, Luca Visconti, Andrea Corsonello, Antonino Catalano, Chiara Chinigò, Salvatore Silipigni, Maria Princiotto, Maria Elsa Gambuzza, Giuseppe Spadaro, Walter Morale, Luca Soraci and Domenico Santoro
Funding Agency and Grant Number
Corresponding Author	Guido Gembillo, Department of Clinical and Experimental Medicine, Department of Nephrology and Dialysis, AOU “G. Martino”, University of Messina, Via Consolare Valeria n 1, Messina 98100, Sicilia, Italy. gembillog@unime.it
Key Words	Chronic kidney disease; Vitamin D; Renal failure; Osteoporosis; Cardiovascular disease
Core Tip	The kidney-bone axis represents a bidirectional endocrine network extending beyond mineral metabolism. Chronic kidney disease affects hundreds of millions worldwide, causing substantially elevated fracture risk and mortality. Traditional biomarkers provide incomplete prognostic value, necessitating novel approaches. The fibroblast growth factor-Klotho pathway emerges as a critical mechanism regulating phosphate homeostasis, bone turnover, and cardiovascular complications, with alterations appearing early in disease progression. Understanding these integrated molecular pathways enables a paradigm shift from symptomatic management toward mechanism-based interventions, offering transformative potential for targeted therapies that simultaneously address skeletal fragility and systemic complications in chronic kidney disease-mineral and bone disorder.
Citation	Gembillo G, Sessa C, Visconti L, Corsonello A, Catalano A, Chinigò C, Silipigni S, Princiotto M, Gambuzza ME, Spadaro G, Morale W, Soraci L, Santoro D. Kidney-bone axis: Emerging paradigms in cross-talk between renal function and skeletal health. World J Orthop 2026; In press

Received	2025-10-22 11:04
Peer-Review Started	2025-10-22 11:04
First Decision by Editorial Office Director	2025-11-10 07:03
Return for Revision	2025-11-10 07:03
Revised	2025-11-23 22:21
Publication Fee Transferred
Second Decision by Editor	2026-02-03 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 08:18
Articles in Press	2026-02-03 08:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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