Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	115681
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Evolution of non-invasive colorectal neoplasm detection
Manuscript Source	Unsolicited Manuscript
All Author List	Sun Jung Kim, Tae-Gyun Lee, Jin-Min Jung and Chang Woo Kim
Funding Agency and Grant Number
Corresponding Author	Chang Woo Kim, MD, PhD, Professor, Department of Surgery, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, South Korea. kcwgkim@gmail.com
Key Words	Blood; Colorectal neoplasms; DNA methylation; Feces; Screening
Core Tip	Non-invasive colorectal cancer (CRC) screening modalities have been developed as alternatives to colonoscopy to improve patient compliance and reduce procedural risks. DNA methylation biomarkers are the key high-performing component of non-invasive CRC screening tests based on stool and blood. Recent advances in next-generation sequencing and machine learning have enabled the integration of multi-omics data into non-invasive CRC screening, facilitating the development of diverse biomarker-based tests across multiple sample types.
Citation	Kim SJ, Lee TG, Jung JM, Kim CW. Evolution of non-invasive colorectal neoplasm detection. World J Gastrointest Oncol 2026; In press

Received	2025-10-27 09:05
Peer-Review Started	2025-10-27 09:06
First Decision by Editorial Office Director	2025-11-21 10:00
Return for Revision	2025-11-23 00:21
Revised	2025-12-04 05:45
Publication Fee Transferred	2025-12-05 05:56
Second Decision by Editor	2026-01-30 02:29
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-30 03:09
Articles in Press	2026-01-30 03:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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