Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	115689
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Increasing expression of presenilin 1, β-catenin and p-PTEN and its regulatory roles on cell invasion in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Xi Lin, Guo-Feng Lin, Fei-Teng Gu and Yong-Liang Li
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Project of Putia 2022S3F006
Corresponding Author	Yong-Liang Li, Director, Department of Gastrointestinal Surgery, Affiliated Hospital of Putian University, No. 999 Dongzhen East Road, Licheng District, Putian 351100, Fujian Province, China. lx05942022@163.com
Key Words	Gastric cancer; Presenilin 1; β-catenin; Phosphorylation of tensin homolog deleted on chromosome ten; Mechanisms of invasion
Core Tip	The high expression of presenilin 1 was correlated with advanced tumor stages, and its expression was positively correlated with both expressions of β-catenin and phosphorylation of tensin homolog deleted on chromosome ten in patients with gastric cancer (GC). The regulation of phosphatase and tensin homolog deleted on chromosome ten phosphorylation and cytoplasmic localization by presenilin 1 through β-catenin, as a novel signal pathway of GC progression, could contribute to GC tumorigenesis.
Citation	Lin X, Lin GF, Gu FT, Li YL. Increasing expression of presenilin 1, β-catenin and p-PTEN and its regulatory roles on cell invasion in gastric cancer. World J Gastrointest Oncol 2025; In press

Received	2025-10-24 07:37
Peer-Review Started	2025-10-24 07:37
First Decision by Editorial Office Director	2025-11-14 01:51
Return for Revision	2025-11-14 01:51
Revised	2025-11-26 11:53
Publication Fee Transferred	2025-12-04 10:33
Second Decision by Editor	2025-12-22 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-22 07:09
Articles in Press	2025-12-22 07:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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