Publication Name	World Journal of Gastroenterology
Manuscript ID	115699
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Dyspepsia following Helicobacter pylori eradication: Shifts in etiology and clinical challenges
Manuscript Source	Invited Manuscript
All Author List	Jian-Guo Lu and Yi-Zhou Gao
Funding Agency and Grant Number
Corresponding Author	Yi-Zhou Gao, Professor, Department of Environmental Hygiene, School of Public Health, Harbin Medical University, No. 157 Baojian Road, Nangang Distinct, Harbin 150081, Heilongjiang Province, China. gaoyizhou@yeah.net
Key Words	Helicobacter pylori; Persistent dyspepsia; Therapeutic strategies; Etiology; Epidemiology
Core Tip	Although Japan has made significant progress in Helicobacter pylori eradication and gastric cancer deaths have declined annually, many patients still suffer from dyspepsia. This challenges the traditional “test-and-eradicate” approach and places a heavy burden on patients. Suzuki et al’s large-scale study (n = 23250) revealed similar post-eradication dyspepsia prevalence (28.7%) to that in uninfected individuals, suggesting a shift from infection to functional factors, such as gastric acid secretion and visceral hypersensitivity. These findings call for individualized symptom-based management, rather than repeated eradication.
Citation	Lu JG, Gao YZ. Dyspepsia following Helicobacter pylori eradication: Shifts in etiology and clinical challenges. World J Gastroenterol 2025; In press

Received	2025-10-22 11:14
Peer-Review Started	2025-10-22 11:14
First Decision by Editorial Office Director	2025-12-02 08:35
Return for Revision	2025-12-02 08:35
Revised	2025-12-14 15:40
Publication Fee Transferred
Second Decision by Editor	2025-12-23 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-23 07:18
Articles in Press	2025-12-23 07:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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