Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115706
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Combined inflammatory markers and amylase levels for early detection of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Jian-Kang Yang, Ya-Qi Gu, Zong-Guo He and Fu-Bao Liu
Funding Agency and Grant Number
Corresponding Author	Fu-Bao Liu, Chief Physician, Department of Hepatobiliary and Pancreas Surgery, The First Affiliated Hospital of Anhui Medical University, Jiankang Road, Xiejiaji District, Hefei 235211, Anhui Province, China. 18155415185@163.com
Key Words	Laparoscopic pancreaticoduodenectomy; Pancreatic fistula; Inflammatory markers; Amylase; Diagnostic accuracy
Core Tip	Clinically relevant postoperative pancreatic fistula remains a major driver of morbidity after laparoscopic pancreaticoduodenectomy; early risk stratification is clinically meaningful. Amylase-related indices (drain fluid amylase concentration, serum amylase concentration, drain-to-serum amylase concentration ratio) reflect pancreatic leakage, while interleukin-6/interleukin-8/C-reactive protein reflect systemic inflammatory burden; combining them improves discrimination. A combined model incorporating amylase indices and inflammatory markers showed high areas under the receiver operating characteristic curve on postoperative day 1 and postoperative day 3, supporting early identification of high-risk patients.
Citation	Yang JK, Gu YQ, He ZG, Liu FB. Combined inflammatory markers and amylase levels for early detection of postoperative pancreatic fistula following laparoscopic pancreaticoduodenectomy. World J Gastrointest Surg 2026; In press

Received	2025-12-16 08:47
Peer-Review Started	2025-12-16 08:47
First Decision by Editorial Office Director	2026-01-06 06:10
Return for Revision	2026-01-06 06:10
Revised	2026-01-12 13:43
Publication Fee Transferred	2026-01-18 09:49
Second Decision by Editor	2026-03-27 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-27 03:01
Articles in Press	2026-03-27 03:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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