Publication Name	World Journal of Obstetrics and Gynecology
Manuscript ID	115708
Country	Kenya

Category	Obstetrics & Gynecology
Manuscript Type	Case Report
Article Title	Cryptococcal antigenemia during pregnancy: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Maureen Mueni Mark, Allan Kariuki Ng’ang’a, Felix Pius Omullo, Gudisa Bereda and Charles Tung’ani Muchiri
Funding Agency and Grant Number
Corresponding Author	Felix Pius Omullo, MD, Senior Researcher, Department of Medical Services, Equity Afya, Kanaamkemer, Lodwar 399-30500, Turkana, Kenya. piuskirasia@gmail.com
Key Words	Cryptococcal antigenemia; Human immunodeficiency virus; Pregnancy; Fluconazole; Antiretroviral therapy; Immune reconstitution inflammatory syndrome; Perinatal transmission; Case report
Core Tip	This case illustrates a high-stakes clinical dilemma in late pregnancy: Adhering to the standard 4-6 week antiretroviral therapy (ART) delay to prevent immune reconstitution inflammatory syndrome (IRIS) vs aggressively suppressing the human immunodeficiency virus viral load to prevent perinatal transmission. We demonstrate that for a woman presenting in the third trimester with isolated antigenemia, a truncated ART delay-supported by preemptive high-dose fluconazole and vigilant monitoring-was a calculated risk that achieved viral suppression for delivery without provoking IRIS. This case argues not for a new guideline, but for nuanced, individualized decision-making in complex scenarios, highlighting a critical evidence gap and the need to better define IRIS risk in pregnant women with antigenemia.
Citation	Mark MM, Ng’ang’a AK, Omullo FP, Bereda G, Muchiri CT. Cryptococcal antigenemia during pregnancy: A case report. World J Obstet Gynecol 2025; In press

Received	2025-10-24 06:28
Peer-Review Started	2025-10-24 06:28
First Decision by Editorial Office Director	2025-11-18 10:36
Return for Revision	2025-11-18 10:36
Revised	2025-11-19 13:53
Publication Fee Transferred
Second Decision by Editor	2025-12-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-25 06:22
Articles in Press	2025-12-25 06:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-6220 (online)
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