Publication Name	World Journal of Gastroenterology
Manuscript ID	115710
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	MassARRAY-based KRAS and GNAS hotspot mutation analysis of cystic fluid enables accurate classification of pancreatic cystic lesions
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Fei Diao, Ming Cui, Tian-Qi Chen, Jin-Heng Xiao, Sen Yang, Qing-Yuan Zheng, Rui-Yuan Xu, Xian-Lin Han and Ya Hu
Funding Agency and Grant Number	Funding Agency Grant Number Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2023-I2M-2-002 National High-Level Hospital Clinical Research Funding 2022-PUMCH-D-001 Peking Union Medical College Hospital Talent Cultivation Program UHB12625 Milstein Medical Asian American Partnership (MMAAP) Foundation Noncommunicable Chronic Diseases-National Science and Technology Major Project 2025ZD0552402
Corresponding Author	Ya Hu, MD, Professor, Department of General Surgery, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. huya@pumch.cn
Key Words	Pancreatic cyst lesions; Cyst fluid analysis; KRAS; GNAS; MassARRAY
Core Tip	Pancreatic cystic lesions (PCLs) are highly heterogenous, which included benign, pre-malignant and malignant lesions. Current diagnostic approaches for PCLs exhibit limited efficacy and accuracy. The implementation of MassARRAY-based KRAS and GNAS mutation analysis of pancreatic cystic fluids improves the precise identification of mucinous cysts and intraductal papillary mucinous neoplasms, thereby providing critical support for clinical decision-making.
Citation	Diao WF, Cui M, Chen TQ, Xiao JH, Yang S, Zheng QY, Xu RY, Han XL, Hu Y. MassARRAY-based KRAS and GNAS hotspot mutation analysis of cystic fluid enables accurate classification of pancreatic cystic lesions. World J Gastroenterol 2026; In press

Received	2025-10-24 09:43
Peer-Review Started	2025-10-24 09:44
First Decision by Editorial Office Director	2025-11-19 10:57
Return for Revision	2025-11-19 10:57
Revised	2025-12-01 16:49
Publication Fee Transferred	2025-12-03 16:10
Second Decision by Editor	2026-02-02 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 01:36
Articles in Press	2026-02-03 01:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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