Publication Name	World Journal of Cardiology
Manuscript ID	115712
Country	Greece

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Georgios Ι Tsironikos, George Ε Zakynthinos, Despoina Kyprianidou, Vasiliki Rammou, Thomas Antonogiannis, Alexandra Bargiota, Epaminondas Zakynthinos and Vasiliki Tsolaki
Funding Agency and Grant Number
Corresponding Author	George Ε Zakynthinos, MD, 3rd Department of Cardiology, "Sotiria" Chest Diseases Hospital, Medical School, National and Kapodistrian University of Athens, Mesogion 152, Athens 11527, Greece. gzakynthinos2@gmail.com
Key Words	Metformin; Cardiovascular disease; Coronary artery disease; New onset type 2 diabetes mellitus; Diabetes prevention; Glucagon-like-peptide-1 receptor agonists; Sodium-glucose cotransporter 2 inhibitors; RCTs
Core Tip	This meta-analysis evaluated the role of metformin in preventing type 2 diabetes among non-diabetic patients with coronary artery disease. Across 933 participants from randomized controlled trials, metformin did not significantly reduce the incidence of diabetes compared to control. The findings were consistent across multiple subgroup analyses, including variations in age, gender, comorbidities, dosage, and follow-up duration. Despite low heterogeneity, the overall quality of evidence was very low, limiting the strength of conclusions. These results suggest that metformin should not be routinely used for diabetes prevention in non-diabetic coronary artery disease patients until more robust evidence from larger trials becomes available.
Citation	Tsironikos GI, Zakynthinos GE, Kyprianidou D, Rammou V, Antonogiannis T, Bargiota A, Zakynthinos E, Tsolaki V. Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis. World J Cardiol 2026; In press

Received	2025-10-24 03:08
Peer-Review Started	2025-10-24 03:08
First Decision by Editorial Office Director	2025-11-19 10:09
Return for Revision	2025-11-19 10:09
Revised	2025-12-02 16:12
Publication Fee Transferred
Second Decision by Editor	2026-02-05 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 03:26
Articles in Press	2026-02-05 03:26
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Typeset the Manuscript

ISSN	1949-8462 (online)
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