Publication Name	World Journal of Psychiatry
Manuscript ID	115720
Country	Mexico

Category	Neurosciences
Manuscript Type	Review
Article Title	Depression and antidepressant drugs: Beyond a purely neurotransmitter approach
Manuscript Source	Invited Manuscript
All Author List	Carlos M Contreras and Ana G Gutiérrez-García
Funding Agency and Grant Number
Corresponding Author	Carlos M Contreras, Emeritus Professor, MD, PhD, Senior Researcher, Unidad Periférica Xalapa, Instituto de Investigaciones Biomédicas, UNAM, Universidad Nacional Autónoma de México, Xalapa 91193, Veracruz, Mexico. ccontreras@uv.mx
Key Words	Stress; Anxiety; Depression; Neuroinflammation; Cerebral plasticity; Antidepressants
Core Tip	Antidepressant drug treatments have been classified based on their actions on neurotransmitters. However, these approaches have not reached solid conclusions about their mechanisms of action, their long latency to achieve clinical efficacy, or the pathophysiological processes that are involved in depression. Recent research suggests a continuum among stress, anxiety, and depression, in which the common denominator is neuroinflammation. Notably, NMDA receptor antagonists and classic antidepressants share actions on neurotrophic factors and glia-neuronal interactions. Therefore, one promising approach for the treatment of pathological anxiety and depression may lie in the search for antiinflammatory drugs with specific actions on neural tissue.
Citation	Contreras CM, Gutiérrez-García AG. Depression and antidepressant drugs: Beyond a purely neurotransmitter approach. World J Psychiatry 2025; In press

Received	2025-10-24 02:55
Peer-Review Started	2025-10-24 02:55
First Decision by Editorial Office Director	2025-11-11 06:40
Return for Revision	2025-11-11 06:40
Revised	2025-11-19 22:26
Publication Fee Transferred
Second Decision by Editor	2025-12-25 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-25 03:04
Articles in Press	2025-12-25 03:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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