Publication Name	World Journal of Diabetes
Manuscript ID	115721
Country	China

Category	Medicine, General & Internal
Manuscript Type	Letter to the Editor
Article Title	Cardiovascular outcomes in high-risk type 2 diabetes mellitus: Standard of care vs multifactorial intensive therapy
Manuscript Source	Invited Manuscript
All Author List	Chun-Fang Dong, Fang He and Guo-Bin Kang
Funding Agency and Grant Number
Corresponding Author	Guo-Bin Kang, Academic Fellow, Department of Cardiology 1, Hebei Provincial Hospital of Chinese Medicine/The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050000, Hebei Province, China. kanggb1229@126.com
Key Words	Type 2 diabetes mellitus; Glycated hemoglobin A1c; Standard of care; Multifactorial intensive therapy; Major adverse cardiovascular events; Mortality
Core Tip	The study by Caturano et al focused on high-risk type 2 diabetes patients and found that an hemoglobin A1c (HbA1c) level ≤ 7% was associated with a reduced incidence of major adverse cardiovascular events only in the standard care group, with no such association observed in the intensive multifactorial treatment group. Additionally, there was a U-shaped relationship between continuous HbA1c levels and adverse outcomes. The study has limitations, but the results support individualized management and emphasize that comprehensive intervention is superior to solely controlling HbA1c.
Citation	Dong CF, He F, Kang GB. Cardiovascular outcomes in high-risk type 2 diabetes mellitus: Standard of care vs multifactorial intensive therapy. World J Diabetes 2025; In press

Received	2025-10-25 08:42
Peer-Review Started	2025-10-27 08:59
First Decision by Editorial Office Director	2025-11-26 08:21
Return for Revision	2025-11-26 08:21
Revised	2025-12-04 06:57
Publication Fee Transferred
Second Decision by Editor	2025-12-22 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-22 05:55
Articles in Press	2025-12-22 05:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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