Publication Name	World Journal of Gastroenterology
Manuscript ID	115723
Country	Mexico

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Toward noninvasive prediction of treatment outcomes in patients with variceal bleeding
Manuscript Source	Invited Manuscript
All Author List	Fernanda M Martínez-Díaz, Elsie A Jiménez-Cuevas, Arnulfo E Morales-Galicia, Mariana M Ramírez-Mejía, Xing-Shun Qi, Jorge L Poo and Nahum Méndez-Sánchez
Funding Agency and Grant Number
Corresponding Author	Nahum Méndez-Sánchez, Liver Research Unit, Medica Sur Clinic and Foundation, Puente de Piedra 150, Colonia Toriello Guerra, Mexico City 14050, Mexico. nmendez@medicasur.org.mx
Key Words	Esophageal and gastric varices; Liver cirrhosis; Portal hypertension; Endoscopic band ligation; Ultrasonography; Elastography
Core Tip	Esophageal variceal bleeding represents one of the most lethal complications of cirrhosis, with high rebleeding and mortality rates despite standard therapy involving endoscopic variceal band ligation. Current follow-up strategies rely on repeated endoscopy and hepatic venous pressure gradient measurements, which are both invasive and resource intensive, whereas noninvasive tools such as elastography and the Baveno criteria lack validation for predicting post-endoscopic variceal band ligation outcomes. Multiparametric ultrasound, by integrating measurement of liver and spleen stiffness with perfusion imaging, offers a comprehensive, noninvasive assessment of portal hypertension and may enable individualized follow-up, reduce procedural burden, and improve patient-centered care.
Citation	Martínez-Díaz FM, Jiménez-Cuevas EA, Morales-Galicia AE, Ramírez-Mejía MM, Qi XS, Poo JL, Méndez-Sánchez N. Toward noninvasive prediction of treatment outcomes in patients with variceal bleeding. World J Gastroenterol 2026; In press

Received	2025-10-24 02:47
Peer-Review Started	2025-10-24 02:48
First Decision by Editorial Office Director	2025-11-24 12:55
Return for Revision	2025-11-24 12:55
Revised	2025-12-17 18:37
Publication Fee Transferred
Second Decision by Editor	2026-01-20 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-20 07:36
Articles in Press	2026-01-20 07:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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