Publication Name	World Journal of Gastroenterology
Manuscript ID	115731
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Gastrointestinal dysfunction after brain injury: Mechanisms and the role of the brain-gut axis
Manuscript Source	Unsolicited Manuscript
All Author List	Xia Zhao, Wei Zhang, Ying Zhang and Xing-An Liu
Funding Agency and Grant Number
Corresponding Author	Xing-An Liu, Department Three of Brain Disease Rehabilitation, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Huaigu District, Shenyang 110032, Liaoning Province, China. liuxing_an@126.com
Key Words	Brain injury; Gastrointestinal dysfunction; Brain-gut axis; Neuroinflammation; Gut microbiota
Core Tip	Brain injury, including traumatic injury and stroke, frequently leads to gastrointestinal dysfunction, manifesting as dysmotility, increased permeability, and dysbiosis. This dysfunction impairs nutrition, increases infection risk, and exacerbates secondary brain damage via systemic inflammation. The brain-gut axis is central to this bidirectional interaction. Investigating interventions like probiotics and vagus nerve stimulation, which modulate this axis, offers promising therapeutic strategies for improving brain injury patient outcomes.
Citation	Zhao X, Zhang W, Zhang Y, Liu XA. Gastrointestinal dysfunction after brain injury: Mechanisms and the role of the brain-gut axis. World J Gastroenterol 2026; In press

Received	2025-10-23 08:37
Peer-Review Started	2025-10-23 08:37
First Decision by Editorial Office Director	2025-11-05 09:13
Return for Revision	2025-11-05 09:13
Revised	2025-11-18 08:03
Publication Fee Transferred	2025-11-19 02:38
Second Decision by Editor	2026-01-12 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 08:37
Articles in Press	2026-01-12 08:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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