Publication Name	World Journal of Stem Cells
Manuscript ID	115733
Country	India

Category	Cell & Tissue Engineering
Manuscript Type	Letter to the Editor
Article Title	Advances in bioengineering and translational progress of stem cell-driven cartilage regeneration
Manuscript Source	Unsolicited Manuscript
All Author List	Sasi Nivruthi, Dilipkumar Preetha and Nagarajan Selvamurugan
Funding Agency and Grant Number
Corresponding Author	Nagarajan Selvamurugan, PhD, Professor, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nādu, India. selvamun@srmist.edu.in
Key Words	Cartilage regeneration; Mesenchymal stem cells; Chondrocyte microenvironment; Chondrocyte hypertrophy; Clinical studies
Core Tip	A review by Cong et al highlighted stem cell-driven cartilage regeneration. Stem cell-based strategies redefine cartilage repair by integrating the regenerative potential of stem cells with tissue-engineering innovations. However, a thorough understanding of the therapeutic potential of these strategies requires consideration of several key aspects. First, careful regulation of progenitor cell differentiation is essential to promote stable chondrocyte formation while preventing hypertrophy. Second, a thorough analysis of clinical studies is required to assess sample sizes and therapeutic efficacy compared with placebo controls. Third, the chondrocyte microenvironment that hosts the bioengineered materials must be addressed.
Citation	Nivruthi S, Preetha D, Selvamurugan N. Advances in bioengineering and translational progress of stem cell-driven cartilage regeneration. World J Stem Cells 2026; In press

Received	2025-10-24 08:01
Peer-Review Started	2025-10-24 08:01
First Decision by Editorial Office Director	2025-11-25 07:46
Return for Revision	2025-11-25 07:46
Revised	2025-11-30 04:17
Publication Fee Transferred
Second Decision by Editor	2026-01-13 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-14 09:09
Articles in Press	2026-01-14 09:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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