Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	115736
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Risk factors and prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Pei-Wen Xu, Qian-Qian Xu, Yan Yu, Yan Jiao, Ya-Hui Liu and Lei Yang
Funding Agency and Grant Number
Corresponding Author	Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130000, Jilin Province, China. yahui@jlu.edu.cn
Key Words	Post-endoscopic retrograde cholangiopancreatography pancreatitis; Risk factors; Prevention; Rectal non-steroidal anti-inflammatory drugs; Pancreatic duct stenting
Core Tip	Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis remains the most frequent and severe complication of ERCP, arising from the interplay of patient and procedural risk factors. Key predictors include female sex, younger age, sphincter of Oddi dysfunction, difficult cannulation, and pancreatic duct manipulation. Evidence strongly supports rectal non-steroidal anti-inflammatory drugs, prophylactic pancreatic duct stenting, and aggressive intravenous hydration as effective preventive measures, particularly in high-risk patients. Recent advances in risk prediction models and artificial intelligence-driven analytics offer opportunities for individualized risk assessment and tailored prophylaxis, which may markedly reduce post-ERCP pancreatitis incidence and improve procedural safety.
Citation	Xu PW, Xu QQ, Yu Y, Jiao Y, Liu YH, Yang L. Risk factors and prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastrointest Endosc 2026; In press

Received	2025-10-24 02:51
Peer-Review Started	2025-10-24 02:51
First Decision by Editorial Office Director	2025-11-25 06:04
Return for Revision	2025-11-27 08:17
Revised	2025-11-28 09:02
Publication Fee Transferred
Second Decision by Editor	2026-01-20 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-20 09:51
Articles in Press	2026-01-20 09:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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