Publication Name	World Journal of Gastroenterology
Manuscript ID	115758
Country	China

Category	Surgery
Manuscript Type	Basic Study
Article Title	Biological welding: A rapid and bloodless approach to hemorrhoidectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Yuan Chen, Qian-Rui Zhang, Ming-Gan Guo, Zhong-Yi Sun and Fan-Chun Zeng
Funding Agency and Grant Number	Funding Agency Grant Number Shenzhen Science and Technology Program No. JCYJ20220531103004008 Talent Introduction Program of Renji Hospital Affiliated to Chongqing University No. 20251028-06 Medicine-Engineering Interdisciplinary Research Foundation of Shenzhen University No. 2023YG018
Corresponding Author	Fan-Chun Zeng, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, No. 3688 Nanhai Avenue, Nanshan District, Shenzhen 518060, Guangdong Province, China. zengisle@szu.edu.cn
Key Words	Biological welding; Hemorrhoidectomy; Surgical time; Blood loss; Recovery time; Pathological analysis
Core Tip	This study demonstrates that biological welding technology, which integrates tissue fusion, cutting, and hemostasis into a single procedure, offers a rapid and bloodless approach to hemorrhoidectomy. In a rabbit model, it significantly reduced operative time by approximately 80%, achieved zero intraoperative blood loss, and accelerated postoperative recovery compared to traditional excision and suturing. Mechanistically, it promotes organized tissue repair by remodeling collagen fibers and reducing inflammation. These findings highlight its potential as a safe, efficient, and innovative surgical technique for clinical application in the treatment of hemorrhoids.
Citation	Chen Y, Zhang QR, Guo MG, Sun ZY, Zeng FC. Biological welding: A rapid and bloodless approach to hemorrhoidectomy. World J Gastroenterol 2026; In press

Received	2025-10-31 14:20
Peer-Review Started	2025-10-31 14:20
First Decision by Editorial Office Director	2025-11-06 09:43
Return for Revision	2025-11-06 09:43
Revised	2025-11-19 08:14
Publication Fee Transferred	2025-12-28 05:51
Second Decision by Editor	2026-01-21 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-21 07:50
Articles in Press	2026-01-21 07:50
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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