Publication Name	World Journal of Hepatology
Manuscript ID	115763
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Qushi Huoxue ointment ameliorates metabolic associated steatotic liver disease through autophagy activation and ferroptosis inhibition
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Yang Liu, Hong Qin, Hong-Xi Wu, Ru-Ting Wang, Qiu-Yan Yang, Feng Jiang, Xu-Dong Liu, De-Kun Wu and You-Ming Tang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) 82160837 Huatong Guokang Medical Research Special Project Grant 2023HT026 Innovation Project of Guangxi Graduate Education YCSW2024405
Corresponding Author	De-Kun Wu, Teaching Experiment and Training Center, Guangxi University of Chinese Medicine, No. 179 Mingxiu East Road, Xixiangtang District, Nanning 530011, Guangxi Zhuang Autonomous Region, China. 1278323777@qq.com
Key Words	Metabolic associated steatotic liver disease; Qushi Huoxue ointment; Autophagy; Ferroptosis; Lipid deposition
Core Tip	Qushi Huoxue ointment can alleviate hepatic lipid accumulation, inflammation, and cell injury in metabolic associated steatotic liver disease mice. Our experimental evidence suggests that these therapeutic effects may be attributed to the concurrent activation of autophagy and inhibition of ferroptosis. The improvement in mitochondrial morphology and the presence of autophagosomes observed under the microscope provide morphological corroboration for this coordinated mechanism.
Citation	Liu YY, Qin H, Wu HX, Wang RT, Yang QY, Jiang F, Liu XD, Wu DK, Tang YM. Qushi Huoxue ointment ameliorates metabolic associated steatotic liver disease through autophagy activation and ferroptosis inhibition. World J Hepatol 2025; In press

Received	2025-11-03 07:13
Peer-Review Started	2025-11-03 07:14
First Decision by Editorial Office Director	2025-11-10 07:02
Return for Revision	2025-11-10 07:02
Revised	2025-11-23 14:20
Publication Fee Transferred	2025-11-24 15:18
Second Decision by Editor	2025-12-24 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-25 03:51
Articles in Press	2025-12-25 03:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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