Publication Name	World Journal of Orthopedics
Manuscript ID	115770
Country	China

Category	Orthopedics
Manuscript Type	Meta-Analysis
Article Title	Machine learning identifies complement factor I as a shared mediator of periodontitis and ossification of posterior longitudinal ligament
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Nan Man, Lu-Yang Zhong, Yue-Liang Wen and Mao-Lin He
Funding Agency and Grant Number
Corresponding Author	Mao-Lin He, PhD, Division of Spinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. hemaolin@stu.gxmu.edu.cn
Key Words	Ossification of the posterior longitudinal ligament; Periodontitis; Complement factor I; Discriminatory biomarker; Machine learning; Transcriptome; Single-cell RNA sequencing
Core Tip	By integrating transcriptomics with machine learning across two distinct conditions, we identified complement factor I (CFI) as a candidate molecular mediator linking periodontitis and ossification of the posterior longitudinal ligament. This study provides the first computational evidence implicating a potential immune-endothelial axis, mediated by CFI, in the shared pathophysiology of these conditions.
Citation	Man YN, Zhong LY, Wen YL, He ML. Machine learning identifies complement factor I as a shared mediator of periodontitis and ossification of posterior longitudinal ligament. World J Orthop 2025; In press

Received	2025-10-27 08:06
Peer-Review Started	2025-10-27 08:06
First Decision by Editorial Office Director	2025-11-21 09:41
Return for Revision	2025-11-21 09:41
Revised	2025-11-29 19:02
Publication Fee Transferred
Second Decision by Editor	2025-12-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-25 06:08
Articles in Press	2025-12-25 06:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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