| Category |
Oncology |
| Manuscript Type |
Observational Study |
| Article Title |
Patient-reported outcome measures for technology assessment: A comparison between three-dimensional conformal and intensity-modulated radiotherapy in prostate cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Arantxa Mera, Gemma Sancho, Olatz Garin, Àngels Pont, Yolanda Pardo, Victor Macias, Asuncion Hervas, Patricia Cabrera, Ferrán Ferrer, Àlvar Roselló, Pilar Samper Ots, María Elena García, Josep Jové-Teixidó, Montse Ferrer and The Multicentric Spanish Group of Clinically Localized Prostate Cancer |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Instituto de Salud Carlos III (ISCIII) and European Union |
No. PI21/00023 |
| Fundación Científica de la Asociación Española Contra el Cáncer |
No. PRYES223070FERR |
| Departament de Recerca i Universitats, Generalitat de Catalunya |
No. AGAUR 2021 SGR 00624 |
|
| Corresponding Author |
Montse Ferrer, PhD, Health Services Research Group, Hospital del Mar Research Institute, CIBER de Epidemiología y Salud Pública (CIBERESP), ISCIII, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, office 140.03 Carrer del Doctor Aiguader 88, First Floor, Barcelona 08003, Catalonia, Spain. mferrer@researchmar.net |
| Key Words |
Prostate cancer; Radiotherapy; Patient-reported outcome measures; Three-dimensional conformal radiotherapy; Intensity-modulated radiotherapy; Quality of life |
| Core Tip |
This study demonstrates the utility of patient-reported outcome measures in assessing technological advances in radiotherapy for localized prostate cancer. By comparing long-term quality-of-life outcomes between three-dimensional conformal radiotherapy and intensity-modulated radiotherapy, it reveals that intensity-modulated radiotherapy – especially when combined with image guidance and reduced margins – was associated with better preservation of urinary continence and bowel function. Conversely, hypofractionation and dose escalation may transiently worsen urinary symptoms. Patient-reported outcome measures capture nuances in patient-centred effects of radiotherapy innovations, supporting their integration into technology assessment frameworks and guiding future optimization strategies. |
| Citation |
Mera A, Sancho G, Garin O, Pont À, Pardo Y, Macias V, Hervas A, Cabrera P, Ferrer F, Roselló À, Samper Ots P, García ME, Jové-Teixidó J, Ferrer M, The Multicentric Spanish Group of Clinically Localized Prostate Cancer. Patient-reported outcome measures for technology assessment: A comparison between three-dimensional conformal and intensity-modulated radiotherapy in prostate cancer. World J Clin Oncol 2026; In press |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
