Publication Name	World Journal of Stem Cells
Manuscript ID	115788
Country	United States

Category	Neurosciences
Manuscript Type	Letter to the Editor
Article Title	Exercise and induced pluripotent stem cells for Parkinson’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Emma Hughes and Brandon Lucke-Wold
Funding Agency and Grant Number
Corresponding Author	Brandon Lucke-Wold, Lillian S Wells Department of Neurosurgery, University of Florida, 1505 SW Archer Road, Gainesville, FL 32608, United States. brandon.lucke-wold@neurosurgery.ufl.edu
Key Words	Parkinson’s disease; Pluripotent stem cells; Neurodegeneration; Dopaminergic neurons; Wnt1; Lmx1a; Exercise
Core Tip	This letter to the editor discusses the recent study by Jiang et al on induced pluripotent stem cells and exercise for Parkinson’s disease. Treatment with induced pluripotent stem cells provides a promising option for Parkinson’s disease patients by replacing lost dopaminergic neurons, while exercise alone has been shown to improve outcomes in these patients. A combination of these therapies has shown a potentially synergistic effect by activating the Wnt1-Lmx1a loop in a mouse model.
Citation	Hughes E, Lucke-Wold B. Exercise and induced pluripotent stem cells for Parkinson’s disease. World J Stem Cells 2026; In press

Received	2025-10-27 08:06
Peer-Review Started	2025-10-27 08:11
First Decision by Editorial Office Director	2025-11-19 10:08
Return for Revision	2025-11-19 10:08
Revised	2025-12-01 19:09
Publication Fee Transferred
Second Decision by Editor	2026-01-12 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 12:44
Articles in Press	2026-01-12 12:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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