Publication Name	World Journal of Gastroenterology
Manuscript ID	115790
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Optimal strategies for mitigating gastrointestinal bleeding in patients receiving antiplatelet therapy: Real-world study
Manuscript Source	Unsolicited Manuscript
All Author List	Minjee Kim, Sang Ah Chi, Ji Eun Kim, Eun Ran Kim, Sung Noh Hong, Young-Ho Kim, Kyunga Kim and Dong Kyung Chang
Funding Agency and Grant Number
Corresponding Author	Dong Kyung Chang, Professor, Department of Medicine, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea. do.chang@samsung.com
Key Words	Gastrointestinal bleeding; Aspirin; Clopidogrel; Proton pump inhibitor; Rebamipide; Antiplatelet therapy; High risk; Low risk; Protective agents; Real-world study
Core Tip	Aspirin and clopidogrel increase the risk of gastrointestinal bleeding; however, the comparative effectiveness of these mucosal protective agents remains unclear. In a large real-world cohort, we found that proton pump inhibitor monotherapy provided substantial protection, whereas combination therapy with rebamipide offered the greatest risk reduction, particularly in high-risk patients. No significant benefit was observed in clopidogrel-alone users or low-risk populations. These findings support a personalized, risk-stratified approach to gastroprotection, and suggest that combination mucosal protective strategies may provide incremental benefits beyond standard regimens.
Citation	Kim M, Chi SA, Kim JE, Kim ER, Hong SN, Kim YH, Kim K, Chang DK. Optimal strategies for mitigating gastrointestinal bleeding in patients receiving antiplatelet therapy: Real-world study. World J Gastroenterol 2026; In press

Received	2025-10-31 13:38
Peer-Review Started	2025-10-31 13:39
First Decision by Editorial Office Director	2025-11-19 11:01
Return for Revision	2025-11-19 11:01
Revised	2025-12-02 04:34
Publication Fee Transferred
Second Decision by Editor	2026-01-29 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-29 07:07
Articles in Press	2026-01-29 07:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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