Publication Name	World Journal of Psychiatry
Manuscript ID	115794
Country	China

Category	Psychiatry
Manuscript Type	Review
Article Title	Role of astrocytes in the development and progression of major depressive disorder
Manuscript Source	Unsolicited Manuscript
All Author List	Pan Jing, Chao Sun, Xiao-Peng Yin, Xi-Cheng Liu, Qing Tian and Xiao-Bin Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Ningbo Top Medical and Health Research Program 2022030410 Zhejiang Medical and Health Science and Technology Project 2023KY1126 Suzhou Clinical Medical Center for Mood Disorders Szlcyxzx202109 Suzhou Key Laboratory SZS2024016 Multicenter Clinical Research on Major Diseases in Suzhou DZXYJ202413
Corresponding Author	Xiao-Bin Zhang, Department of Psychiatry, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, No. 11 Guangqian Road, Xiangcheng District, Suzhou 215137, Jiangsu Province, China. zhangxiaobim@163.com
Key Words	Astrocytes; Major depressive disorder; Glial fibrillary acidic protein; S100β protein; Glial cell line-derived neurotrophic factor; Physiological functions
Core Tip	Major depressive disorder is one of the most prevalent psychiatric illnesses worldwide which impairs the social functioning of the afflicted patients. Astrocytes play a role in the maintenance of the function of the central nervous system, both physiologically and pathologically. Increasing evidence suggests that the number, volume and function of astrocytes are altered in the depressed brain. The glial fibrillary acidic protein and S100β protein, which are closely associated with astrocytes, also show significant alterations in patients with major depressive disorder. Astrocyte-derived glial cell line-derived neurotrophic factor not only exerts neuroprotective effects in the central and peripheral nervous systems but also plays a role in depressive symptomatology and the pharmacological action of antidepressant treatments.
Citation	Jing P, Sun C, Yin XP, Liu XC, Tian Q, Zhang XB. Role of astrocytes in the development and progression of major depressive disorder. World J Psychiatry 2026; In press

Received	2025-10-27 11:22
Peer-Review Started	2025-10-27 11:22
First Decision by Editorial Office Director	2025-11-28 06:33
Return for Revision	2025-11-28 06:33
Revised	2025-12-14 01:02
Publication Fee Transferred	2025-12-17 06:30
Second Decision by Editor	2026-01-15 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-15 05:42
Articles in Press	2026-01-15 05:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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