Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115798
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	T-LAK cell-originated protein kinase promotes tumorigenesis and metastasis of pancreatic neuroendocrine neoplasms via mitogen-activated protein kinase axis activation
Manuscript Source	Unsolicited Manuscript
All Author List	Meng Meng, Qing Chen, Meng Yuan, Xin Guo, Si-Qian Ren and Chun-Hui Yuan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81672862 the National Science and Technology Major Project of China 2025ZD0552411
Corresponding Author	Chun-Hui Yuan, MD, Department of General Surgery, Peking University Third Hospital, No. 49 Huayuan North Road, Haiding District, Beijing 100191, China. ychdoctor@bjmu.edu.cn
Key Words	T-LAK cell-originated protein kinase; Pancreatic neuroendocrine neoplasms; Mitogen-activated protein kinase axis; Invasiveness and metastasis; HI-TOPK-032
Core Tip	Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare and typically slow growing but may lead to serious health complications. T-LAK cell-derived protein kinase is a serine/threonine kinase originally identified from a cDNA library of lymphokine-activated killer T cells and is overexpressed in multiple malignancies. This study demonstrates that T-LAK cell-derived protein kinase is markedly overexpressed in pNENs tissues with liver metastasis and further clarifies its effects on downstream signaling and the malignant biological behavior of pNENs.
Citation	Meng M, Chen Q, Yuan M, Guo X, Ren SQ, Yuan CH. T-LAK cell-originated protein kinase promotes tumorigenesis and metastasis of pancreatic neuroendocrine neoplasms via mitogen-activated protein kinase axis activation. World J Gastrointest Surg 2026; In press

Received	2025-11-21 09:12
Peer-Review Started	2025-11-21 09:12
First Decision by Editorial Office Director	2025-12-16 07:07
Return for Revision	2025-12-16 07:07
Revised	2025-12-19 10:49
Publication Fee Transferred	2025-12-23 09:42
Second Decision by Editor	2026-02-09 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 03:40
Articles in Press	2026-02-09 03:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com