Publication Name	World Journal of Gastroenterology
Manuscript ID	115807
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Strategic integration of immunotherapy with chemotherapy, radiotherapy, and targeted therapy in gastric cancer management: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Yashwant Kumar Ratre, Nilabh Ghritlahre, Babita Pande, Tarun Sahu, Lakkakula Suhasini Sahithi, Shashikant Swarnkar and Henu Kumar Verma
Funding Agency and Grant Number
Corresponding Author	Henu Kumar Verma, Assistant Professor, Department of Bioscience and Biomedical Engineering, Indian Institute of Technology, Kutelabhata, Bhilai 491002, Chhattisgarh, India. henu.verma@yahoo.com
Key Words	Gastric cancer; Immunotherapy; Chemotherapy; Radiotherapy; Targeted therapy; Management
Core Tip	Gastric cancer remains challenging to treat due to late diagnosis and limited response to standard therapies. Immunotherapy, especially programmed cell death 1/programmed cell death ligand 1 inhibitors like pembrolizumab and nivolumab, has shown promising results in improving survival. This systematic review emphasizes the benefits of integrating immunotherapy with chemotherapy, radiotherapy, and targeted therapy to enhance antitumor efficacy through mechanisms such as immunogenic cell death and the abscopal effect. Future studies should focus on optimizing treatment sequencing, dosing, and biomarker-based patient selection to refine combination strategies and improve survival and quality of life in gastric cancer patients.
Citation	Ratre YK, Ghritlahre N, Pande B, Sahu T, Sahithi LS, Swarnkar S, Verma HK. Strategic integration of immunotherapy with chemotherapy, radiotherapy, and targeted therapy in gastric cancer management: A systematic review. World J Gastroenterol 2026; In press

Received	2025-10-27 11:54
Peer-Review Started	2025-10-27 11:54
First Decision by Editorial Office Director	2025-11-14 09:24
Return for Revision	2025-11-14 09:24
Revised	2025-12-22 12:09
Publication Fee Transferred
Second Decision by Editor	2026-02-10 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-10 11:19
Articles in Press	2026-02-10 11:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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