Publication Name	World Journal of Diabetes
Manuscript ID	115813
Country	China

Category	Ophthalmology
Manuscript Type	Letter to the Editor
Article Title	Indirect bilirubin: A potential predictive biomarker for diabetic retinopathy and its clinical translational potential
Manuscript Source	Unsolicited Manuscript
All Author List	Zhao Zhang, Xiao-Qian Shan, Feng-Ming Liang and Li-Xia Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82174442
Corresponding Author	Li-Xia Zhang, . zhanglixia77@126.com
Key Words	Biomarker; Diabetic retinopathy; Indirect bilirubin; Type 2 diabetes mellitus
Core Tip	Diabetic retinopathy (DR) remains a leading cause of vision loss and blindness among individuals with type 2 diabetes. A critical need exists for reliable biomarkers that can facilitate early identification and diagnosis of DR, as the absence of such markers significantly impedes timely intervention and effective management. The study by Lin et al reveals that "IBIL levels are independently and inversely associated with DR risk, suggesting its potential as a low-cost, non-invasive, and readily applicable predictive biomarker". To facilitate a comprehensive understanding of this novel predictive indicator, this review first evaluates the potential of indirect bilirubin in DR risk prediction from both basic science and clinical perspectives. It subsequently addresses the advantages and challenges associated with its application as a predictive biomarker and concludes with projections on its future role in DR screening strategies.
Citation	Zhang Z, Shan XQ, Liang FM, Zhang LX. Indirect bilirubin: A potential predictive biomarker for diabetic retinopathy and its clinical translational potential. World J Diabetes 2025; In press

Received	2025-10-27 01:42
Peer-Review Started	2025-10-27 08:58
First Decision by Editorial Office Director	2025-12-03 10:01
Return for Revision	2025-12-03 10:01
Revised	2025-12-15 05:49
Publication Fee Transferred
Second Decision by Editor	2025-12-31 02:31
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-31 03:37
Articles in Press	2025-12-31 03:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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