Publication Name	World Journal of Clinical Cases
Manuscript ID	115814
Country	Morocco

Category	Immunology
Manuscript Type	Letter to the Editor
Article Title	Human leukocyte antigen variants and clinical features of primary biliary cholangitis: Cumulative contributions
Manuscript Source	Invited Manuscript
All Author List	Abdellatif Bouayad
Funding Agency and Grant Number
Corresponding Author	Abdellatif Bouayad, Associate Professor, MD, Department of Immunology, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, 4867 Oujda l’Université, Oujda 60049, Morocco. a.bouayad@ump.ac.ma
Key Words	Human leukocyte antigen class II; Human leukocyte antigen-G; Primary biliary cholangitis; Prognosis; Primary biliary cholangitis-autoimmune hepatitis overlap syndrome; Therapy response
Core Tip	Specific classical human leukocyte antigen (HLA) alleles and haplotypes may influence predisposition to primary biliary cholangitis (PBC), prognosis, and the development of PBC-autoimmune hepatitis overlap syndrome. Potential cumulative contributions between the non-classical HLA-G*01: 01: 01: 08-UTR-1 haplotype and its soluble HLA-G molecules may predict a poor therapeutic response to ursodeoxycholic acid. Thus, soluble HLA-G molecules may serve as novel, non-invasive biomarkers to guide personalized PBC treatment.
Citation	Bouayad A. Human leukocyte antigen variants and clinical features of primary biliary cholangitis: Cumulative contributions. World J Clin Cases 2026; In press

Received	2025-10-27 07:39
Peer-Review Started	2025-10-27 07:40
First Decision by Editorial Office Director	2026-01-08 03:49
Return for Revision	2026-01-08 03:49
Revised	2026-01-15 15:34
Publication Fee Transferred
Second Decision by Editor	2026-02-04 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-04 07:18
Articles in Press	2026-02-04 07:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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