Publication Name	World Journal of Diabetes
Manuscript ID	115820
Country	India

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Letter to the Editor
Article Title	Beyond glycated hemoglobin: Redefining success in diabetes through multifactorial cardiometabolic care
Manuscript Source	Invited Manuscript
All Author List	Manjeet Kumar Goyal, Juniali Hatwal, Rupak Desai and Akash Batta
Funding Agency and Grant Number
Corresponding Author	Akash Batta, Assistant Professor, DM, MD, Department of Cardiology, Dayanand Medical College and Hospital, Tagore Nagar, Civil Lines, Ludhiana 141001, Punjab, India. akashbatta02@gmail.com
Key Words	Diabetes; Glycated hemoglobin; Cardiovascular risk; Glycaemic control; Macrovascular complications
Core Tip	The post hoc analysis of the NEPHRODIAB (nephropathy in diabetes type 2) cohort by Caturano et al challenges the long-held assumption that tighter glycemic control uniformly improves cardiovascular outcomes in type 2 diabetes. Among high-risk patients with microvascular disease, achieving glycated hemoglobin ≤ 7% predicted better cardiovascular survival only under standard care and not only within a structured multifactorial intensive-therapy framework, where other risk factors were tightly managed. These findings suggest that the prognostic value of glycemic control depends on the broader treatment context: Once blood pressure, lipids, and other risks are optimized, further glucose lowering offers limited additional benefit. Thus, individualized targets and risk-factor–based care remains central to diabetes management.
Citation	Goyal MK, Hatwal J, Desai R, Batta A. Beyond glycated hemoglobin: Redefining success in diabetes through multifactorial cardiometabolic care. World J Diabetes 2026; In press

Received	2025-10-27 01:40
Peer-Review Started	2025-10-27 09:15
First Decision by Editorial Office Director	2025-11-18 09:39
Return for Revision	2025-11-18 09:39
Revised	2025-11-24 05:09
Publication Fee Transferred
Second Decision by Editor	2026-01-08 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-08 08:10
Articles in Press	2026-01-08 08:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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