Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115825
Country	Italy

Category	Surgery
Manuscript Type	Minireviews
Article Title	Mucinous rectal adenocarcinoma and neoadjuvant therapy: Implications for surgical practice
Manuscript Source	Unsolicited Manuscript
All Author List	Alberto Patriti, Francesco Graziano and Rita Chiari
Funding Agency and Grant Number
Corresponding Author	Alberto Patriti, MD, PhD, Department of Surgery, Division of General and Robotic Surgery, Azienda Sanitaria Territoriale di Pesaro-Urbino, Ospedale San Salvatore Piazzale Cinelli, 1, Pesaro 61121, Italy. albertopatriti@gmail.com
Key Words	Rectal cancer; Mucinous adenocarcinoma; Total mesorectal excision; Surgery; Total neoadjuvant therapy; Radiotherapy; Multivisceral resection; Watch-and-Wait
Core Tip	Mucinous adenocarcinoma (MAC) is a distinct histologic subtype characterized by abundant extracellular mucin and a reduced response to neoadjuvant chemoradiotherapy or total neoadjuvant therapy (TNT). This review integrates molecular, radiologic, and surgical evidence to explain why MAC behaves differently and how meticulous total mesorectal excision can mitigate these challenges. When tumor downstaging and complete (R0) resection are achieved after TNT, long-term outcomes may be comparable to non-MAC, underscoring the importance of surgical precision and multidisciplinary planning.
Citation	Patriti A, Graziano F, Chiari R. Mucinous rectal adenocarcinoma and neoadjuvant therapy: Implications for surgical practice. World J Gastrointest Surg 2026; In press

Received	2025-10-27 13:26
Peer-Review Started	2025-10-27 13:28
First Decision by Editorial Office Director	2025-11-05 06:01
Return for Revision	2025-11-05 06:01
Revised	2025-11-19 21:50
Publication Fee Transferred	2025-12-03 21:05
Second Decision by Editor	2026-02-14 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-14 08:10
Articles in Press	2026-02-14 08:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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