Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	115835
Country	Greece

Category	Oncology
Manuscript Type	Minireviews
Article Title	From bench to bedside: Stem cell applications in gastric cancer therapy and their emerging clinical relevance
Manuscript Source	Invited Manuscript
All Author List	Ioana A Prisacariu, Konstantinos E Koumarelas, Panagiotis Papadopoulos, Dimitrios Schizas and Grigorios Christodoulidis
Funding Agency and Grant Number
Corresponding Author	Grigorios Christodoulidis, MD, PhD, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Thessalia, Greece. gregsurg@yahoo.gr
Key Words	Gastric cancer; Gastric cancer stem cells; Stemness; Tumor microenvironment; Therapy resistance; Biomarkers; Precision medicine
Core Tip	Gastric cancer stem cells (GCSCs) are key mediators of recurrence, metastasis, and therapy resistance. Understanding their regulation through signaling pathways, epigenetic mechanisms, and tumor microenvironmental support provides opportunities for novel therapeutic interventions. This review highlights the clinical relevance of GCSCs, current mechanistic insights, and emerging strategies such as RNA-based therapies, immunotherapy, and nanotechnology offering a precision medicine framework to improve outcomes in gastric cancer.
Citation	Prisacariu IA, Koumarelas KE, Papadopoulos P, Schizas D, Christodoulidis G. From bench to bedside: Stem cell applications in gastric cancer therapy and their emerging clinical relevance. World J Gastrointest Oncol 2025; In press

Received	2025-10-27 07:47
Peer-Review Started	2025-10-27 07:48
First Decision by Editorial Office Director	2025-11-05 07:46
Return for Revision	2025-11-05 07:46
Revised	2025-11-16 20:18
Publication Fee Transferred
Second Decision by Editor	2025-12-23 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-23 08:49
Articles in Press	2025-12-23 08:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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