Publication Name	World Journal of Clinical Cases
Manuscript ID	115845
Country	China

Category	Pediatrics
Manuscript Type	Case Report
Article Title	Preterm heart failure and refractory lactic acidosis caused by congenital hypothyroidism: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Ju Chen, Jiao Li, Xiao-Ming Xu, Bo Zhang, Bo-Chao Cheng and Jing Shi
Funding Agency and Grant Number	Funding Agency Grant Number Clinical Research Funding of West China Second University Hospital, Sichuan University KL075 Xizang Autonomous Region Science and Technology Program XZ202501JD0017 National Natural Science Foundation of China 81501304 Sichuan Science and Technology Program 22ZDYF0831
Corresponding Author	Jing Shi, PhD, Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20, section 3, Renmin South Road, Wuhou District, Chengdu 610041, Sichuan Province, China. shijing@scu.edu.cn
Key Words	Congenital hypothyroidism; Lactic acidosis; Heart failure; Neonate; Preterm; Case report
Core Tip	This report details a critical case of congenital hypothyroidism in a preterm infant, presenting as severe heart failure and refractory lactic acidosis. The infant showed a rapid, life-saving response to levothyroxine, highlighting congenital hypothyroidism’s role as a reversible cause of cardiovascular collapse. A key novelty is the profound lactic acidosis, a rarely reported feature of neonatal hypothyroidism. This case underscores the need for high clinical suspicion and repeat screening in preterm infants with unexplained heart failure or metabolic acidosis. Our findings advance understanding of thyroid hormones’ role in cardiac metabolism and confirm that prompt treatment is vital for excellent outcomes.
Citation	Chen HJ, Li J, Xu XM, Zhang B, Cheng BC, Shi J. Preterm heart failure and refractory lactic acidosis caused by congenital hypothyroidism: A case report and review of literature. World J Clin Cases 2025; In press

Received	2025-11-07 09:18
Peer-Review Started	2025-11-07 09:18
First Decision by Editorial Office Director	2025-11-18 09:58
Return for Revision	2025-11-18 09:58
Revised	2025-12-01 07:41
Publication Fee Transferred	2025-12-08 15:09
Second Decision by Editor	2025-12-22 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-22 09:45
Articles in Press	2025-12-22 09:45
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Typeset the Manuscript

ISSN	2307-8960 (online)
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