Publication Name	World Journal of Gastroenterology
Manuscript ID	115846
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Research progress on co-morbidity between gastrointestinal and pulmonary diseases from the perspective of the gut-lung axis
Manuscript Source	Invited Manuscript
All Author List	Hao-Jun Huang, Pan-Pan Liu and De-Feng Dong
Funding Agency and Grant Number
Corresponding Author	Hao-Jun Huang, School of Nursing, Yanbian University, No. 977 Gongyuan Road, Yanji 133000, Jilin Province, China. hy86382211@163.com
Key Words	Microbiota; Comorbidity mechanism; Lung diseases; Gastrointestinal diseases; Gut-lung axis
Core Tip	The gut-lung axis represents a bidirectional communication network that links the gastrointestinal and respiratory systems through microbial, immune, and metabolic pathways. This review synthesizes recent advances in understanding how gut dysbiosis, microbial translocation, immune dysregulation, and epigenetic modifications contribute to gastrointestinal-pulmonary comorbidities. We highlight key clinical phenotypes and explore emerging therapeutic strategies, including microbiota-targeted interventions, metabolite supplementation, and immune modulation. Future efforts should emphasize multi-omics integration, organoid-based models, and AI-driven predictive analytics to advance precision medicine anchored in the gut-lung axis.
Citation	Huang HJ, Liu PP, Dong DF. Research progress on co-morbidity between gastrointestinal and pulmonary diseases from the perspective of the gut-lung axis. World J Gastroenterol 2026; In press

Received	2025-10-27 04:18
Peer-Review Started	2025-10-27 04:18
First Decision by Editorial Office Director	2025-11-19 10:57
Return for Revision	2025-11-19 10:57
Revised	2025-12-02 15:26
Publication Fee Transferred
Second Decision by Editor	2026-01-14 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-14 07:07
Articles in Press	2026-01-14 07:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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