Publication Name	World Journal of Clinical Oncology
Manuscript ID	115882
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Lactylation in pancreatic cancer: From molecular mechanisms to therapeutic perspectives
Manuscript Source	Unsolicited Manuscript
All Author List	Gabriel Dickson Hawanga, Zhao-Xing Li, Mao-Xin Li, Xiu-Lei Zhang and Dao-Hai Qian
Funding Agency and Grant Number
Corresponding Author	Dao-Hai Qian, Associate Chief Physician, Associate Professor, MD, PhD, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu 241001, Anhui Province, China. 20161106@wnmc.edu.cn
Key Words	Lactylation; Epigenetic; Metabolic reprogramming; Lactate; Pancreatic ductal adenocarcinoma; Tumor microenvironment
Core Tip	This mini-review highlights lactylation, a lactate-derived epigenetic modification, as a pivotal mechanism linking the intense glycolytic metabolism of pancreatic ductal adenocarcinoma to its aggressive phenotype. We synthesize how lactylation of histones and non-histone proteins drives oncogenic transcription, chemoresistance, and immune suppression. The article critically evaluates the promise of targeting lactylation “writers” and “erasers”, lactate transporters, and metabolic enzymes for therapy, while also discussing the challenges of specificity, drug delivery, and biomarker validation that must be addressed to translate these strategies to the clinic.
Citation	Hawanga GD, Li ZX, Li MX, Zhang XL, Qian DH. Lactylation in pancreatic cancer: From molecular mechanisms to therapeutic perspectives. World J Clin Oncol 2026; In press

Received	2025-10-29 13:57
Peer-Review Started	2025-10-29 13:57
First Decision by Editorial Office Director	2025-11-19 10:11
Return for Revision	2025-11-19 10:11
Revised	2025-11-23 19:52
Publication Fee Transferred	2025-11-24 02:21
Second Decision by Editor	2026-01-12 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 07:32
Articles in Press	2026-01-12 07:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com